Lukas Dow, Professor of Biochemistry in Medicine
Tissue: Pancreas, Colon, Small Intestine
Disease: Cancer
Species: Mouse
Modifications: Targeted Mutation
Description: Series of genetically engineered organoids derived from mouse pancreas, colon, and small intestine. Organoids were
generated from either wild-type tissue, or animals carrying specific tissue restricted transgenes, and further manipulated in culture to generate targeted mutations in oncogenes and tumor suppressors. Organoids carry CRISPR engineered mutations in Apc and/or p53. The organoids also carry Cre-conditional KRAS alleles, including G12D, G12C, G12R, and G13D mutations.
Availability: Available by license from WCM.
*Availability and licensing conditions are subject to change.
Publications
Intellectual Property
Cornell Reference
- D-9448
Contact Information
For additional information please contact
Iris Bica
Business Development and Licensing Associate
Phone: (646) 962-5966
Email: ib342@cornell.edu