Li Gan, Burton P. and Judith B. Resnick Distinguished Professor in Neurodegenerative Diseases and Professor of Neuroscience
Name: C57BL/6J-Trem2tm1(TREM2*R47H)Lgn
Strain: N/A
Modification: Knock-in
Description: hTREM2-R47H knock-in mice contain a CRISPR/cas9 generated insertion of R47H-hTREM2 that replaces the mTREM2 allele. The R47H variant elevates Alzheimer’s Disease risk by 2-4.5-fold, and is associated with earlier AD onset, faster cognitive decline, and increased tau pathology.
Application: Mouse model useful for studying R47H point mutation in Alzheimer’s Disease.
Availability: Available from WCM.
*Availability and licensing conditions are subject to change.
Publications
Intellectual Property
Cornell Reference
- D-10556
Contact Information
For additional information please contact
Iris Bica
Business Development and Licensing Associate
Phone: (646) 962-5966
Email: ib342@cornell.edu