Melody Zeng, Associate Professor of Immunology in Pediatrics
Name: C57BL/6J-Del(12Ighg3-Ighg2b)1Mzeng/J
Strain: 038643
Modification: Knock-out
Description: IgG knock-out mice contain an CRISPR/cas9generated 80 kbp deletion that removes IgG isotypes Ighg1, Ighg2a, Ighg2b, and Ighg3. Homozygous mice develop an altered gut microbiome that promotes differentiation of IL17Aproducing δγT cells in the small intestine and colon.
Application: Mouse model to study enteric pathogens and the gut microbiome.
Availability: Available from JAX with license from WCM.
*Availability and licensing conditions are subject to change.
Publications
Intellectual Property
Cornell Reference
- D-10399
Contact Information
For additional information please contact
Iris Bica
Business Development and Licensing Associate
Phone: (646) 962-5966
Email: ib342@cornell.edu