Lukas Dow, Professor of Biochemistry in Medicine
Name: B6;129S4-Krasem1Ldow/J
Strain: 033068
Modification: Endonuclease-mediated mutation
Description: LSL-KrasG12C mice carry a CRISPR/cas9 generated mutation (G12C) in Kras commonly found in lung cancer. Expression of this mutant is blocked by a loxP-flanked stop codon. Cre-mediated recombination allows for the oncogenic protein to be expressed by excising the stop codon.
Application: Mouse strain useful for studying lung cancer.
Availability: Available from JAX with license from WCM.
*Availability and licensing conditions are subject to change.
Publications
Intellectual Property
Cornell Reference
- D-8465
Contact Information
For additional information please contact
Iris Bica
Business Development and Licensing Associate
Phone: (646) 962-5966
Email: ib342@cornell.edu