Lukas Dow, Professor of Biochemistry in Medicine
Name: B6N.129S4-Krasem3Ldow/J
Strain: 033317
Modification: Endonuclease-mediated mutation
Description: LSL-KrasG13D mice carry a CRISPR/cas9 generated mutation (G13D) in Kras commonly found in colon cancer. Expression of this mutant is blocked by a loxP-flanked stop codon. Cre-mediated recombination allows for the oncogenic protein to be expressed by excising the stop codon.
Application: Mouse strain useful for studying colon cancer.
Availability: Available from JAX with license from WCM.
*Availability and licensing conditions are subject to change.
Publications
Intellectual Property
Cornell Reference
- D-8465
Contact Information
For additional information please contact
Iris Bica
Business Development and Licensing Associate
Phone: (646) 962-5966
Email: ib342@cornell.edu