MGS34F Mouse

Name: B6.Cg-U2af1tm1.1Hev/J

Strain: 032638

Modification: Targeted mutation

Description: MGS34F mice carry loxP-sites that flank exon 2-8 of U2af1 followed by a transcriptional STOP cassette and an S34F mutation in exon 2 of the gene seen in myelodysplastic syndromes (MDS). Cre-mediated excision of the of the STOP cassette allows for the expression of the mutant and mice to develop impaired blood cells with MDS-like features accompanied by abnormal splicing patterns.

Application: Mouse model to study splicing factor mutation in U2AF1 commonly found in MDS and acute myeloid leukemia.

Availability: Available from JAX with license from WCM.

*Availability and licensing conditions are subject to change.