RPE(∆Clic4)Mouse

Name: C57BL/6J-Clic4tm1.1Aidi;Tg(Best1-cre)1Jdun

Strain: N/A

Modification: Knock-out

Description: RPE∆Clic4 mice have a retinal pigment epitheliumspecific knockout of the Clic4 gene. These mice exhibit pathological and functional hallmarks of dry age-related macular degeneration (AMD), including drusen-like deposits, RPE cell death, and photoreceptor degeneration, due to aberrant lipid metabolism and transport.

Application: Mouse model useful in studies of age-related macular degeneration (AMD) and retinal diseases.

Availability: Available from WCM.

*Availability and licensing conditions are subject to change.