S1p1(f/stop/f)Mouse

Name: B6.C-Gt(ROSA)26Sortm1(CAG-S1pr1)Thla/J

Strain: 030438

Modification: Targeted mutation

Description: In S1p1f/stop/f mice, Cre-mediated excision of a floxed STOP enables tissue-specific overexpression of S1pr1. Overexpression results in decreased endothelial sprouting angiogenesis with reduced vascular network, vessel density, tip cells and branch points. 

Application: Mouse model useful in studies related to endothelial angiogenesis and vascular development. 

Availability: Available from JAX with license from WCM.

*Availability and licensing conditions are subject to change.