Jochen Buck, Professor of Pharmacology
Lonny Levin, Professor of Pharmacology
Modification: Conditional knock-out
Description: Conditional soluble adenylyl cyclase (sAC; Adcy10) floxed mice were generated by flanking exons 11–13 of the gene with loxP sites, targeting the region encoding the C2 catalytic domain of soluble adenylyl cyclase. An FRT-flanked neomycin selection cassette was initially included and subsequently removed via Flp recombinase, leaving intact loxP sites for conditional gene targeting. These mice enable tissue-specific and/or inducible deletion of Adcy10 when crossed with Cre recombinase-expressing lines.
Applications: Conditional mouse model to study spatial and temporal roles of sAC.
Availability: Available from WCM.
*Availability and licensing conditions are subject to change.
Publications
Intellectual Property
Cornell Reference
- D-10263
Contact Information
For additional information please contact
Ivan Gando
Business Development and Licensing Associate
Phone: (646) 814-6459
Email: ivan.gando@cornell.edu