Giovanni Manfredi, Professor of Neuroscience
Tissue: Other
Species: Human
Disease: Cytochrome c oxidase deficiency
Modifications: COX I mutation, Cybrid
Description: Transmitochondrial cell lines containing various proportions of G6930A stop-codon mutation in COX I gene. COX enzymatic activity decreases as the levels of mutated mtDNA increase; similarly, COX I polypeptide synthesis and their steadystate levels also decrease with higher amounts of mutated mtDNA. Cell respiration and ATP synthesis are preserved in cells with lower proportions (~40%) of mutated genomes.
Availability: Available from WCM for internal research use. Not available for inclusion in repositories.
*Availability and licensing conditions are subject to change.
Publications
Intellectual Property
Cornell Reference
- D-6148
Contact Information
For additional information please contact
Iris Bica
Business Development and Licensing Associate
Phone: (646) 962-5966
Email: ib342@cornell.edu